Inside News
GAIT Trial Results
Current News
Past News

Home Page
Q & A
About Dr. Theo

The Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
Results, Commentary and Analysis
by (Jason Theodosakis, MD, MS, MPH, FACPM) Member of the Study's Oversight Steering Committee




GAIT Part 1 (2006) Results and Commentary


Full Results of GAIT (all 42 outcomes)

GAIT News Flash: Celebrex fails to exceed placebo in 40/42 outcome measures - missed data by media reporters, faulty conclusions


"Combination of glucosamine and chondroitin is effective in treating moderate to severe knee pain due to OA. The lack of response in patients with mild pain may be due to a floor effect, limiting ability to detect response. All study agents were well tolerated."

Arthritis & Rheumatism Vol. 52, No. 9 (suppl.) p. S256


The supplements significantly improved pain and function in 79% of subjects and clearly outperformed the prescription drug Celebrex for those people who had the most pain to start the 6-month study.

The high placebo rate washed out or diluted the results of those with mild/moverate pain. That's what is meant by the "floor effect."

Glucosamine/Chondroitin vs. Celebrex Comparison Chart


"Since Celebrex should not be used for people with only mild arthritis pain, was equal to placebo for those who had moderate to severe pain, costs about $3/day, often requires one to take an acid blocker (additional $1-$4/day), causes high blood pressure, kidney damage and thousands of deaths per year, one has to question if physicians who prescribe Celebrex are violating the Hippocratic Oath (to Do No Harm.) Despite the fact that I own stock in the maker of Celebrex (Pfizer), I would advise against using Celebrex or related drugs unless absolutely necessary. Click for an in-depth analysis of the GAIT findings. "

Dr. Theo


This page has been put in to sections to make it easier for you to read online. Please use the following navigation to get started and following the navigation links at the bottom of subsequent pages:

History - Drug Dangers

Origins and Steps

Purpose and Results

Commentary on the meaning of the results by Dr. Theo

This study was originally conceived in January 1998 in response to the 1997 #1 New York Times bestseller - "The Arthritis Cure," the groundbreaking treatment program for osteoarthritis.

In this book, I created a nine-step, integrative treatment program for osteoarthritis, the number one cause of chronic pain and disability. I revised the book in 2004 to add new components to the nine steps.

Step 2 suggested the use of the dietary supplement combination of glucosamine and chondroitin. I theorized that combining the supplements would have a synergistic (more than additive) effect for relieving pain and improving function.

The US government's NIH (National Institute of Health) wanted to validate (or refute) my theory in an effort to substantiate the use of glucosamine and chondroitin as a replacement for prescription and over-the-counter drugs.


Learn about and purchase the book

90% of people who follow The Arthritis Cure treatment program don't need anti-inflammatories (like Aleve, Celebrex or Advil).
Dr. Theo warned people that these drugs, used first... read more



Copyright 1997-2005 Jason Theodosakis, M.D.
Privacy Policy
Please read this site's disclaimer.