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Medical Evidence

[A German Pharmacokinetic Study on Oral Chondroitin Sulfate] (Orale Chondroitinsulfatmedikation zur Behandlung von Arthrosen) D. Gross Klinik fur Rheurnatologie und Rehabilitation (Chefarzt: Prof. Dr. D. Gross), Stadtspital Triemli, Zurich/Schweiz

Summary: The subject of this paper is the question If chondroitin sulfate taken by mouth Is resorbed by the gastro-Intestinal tract or not. For this the concentration in plasma and in joint fluid has been measured after an oral medication of 3.0 g Chondrosuf® IBSA. 3 and 6 hours after the administration the levels of chondroitin sulfates were higher as before as well in plasma as in joint synovia. In a second experiment 0.5 g and 1.0 g Chondrosuf® has been administrated for a long term of 40 weeks. The concentration in synovial fluid was measured. The levels were elevated after the administration of 0.8 g and 1.0 g Chondrosuf®, but not with a dosage of 0.5 g. By this reason an administration of more than 0.8 g Chondrosuf® is not senseless as basic treatment in patients with osteoarthritis. A clinical trial in 45 paVents with osteoarthritis of knee joints had first the goal of compatibility of Chondrosuf® of the gastrointestinal tract, and in a general view (allergy). The compatibility of the drug is very good. In 45 patients 1 exanthema, 2 diarrheas and 1 troubles of the stomach could be found. The effectivity of the drug from the subjective point of view especially the reduction of osteoarthritic pains was the second goal.

Source: THERAPIEWOCHE 33, 4238-4244 (1983)

Dr. Theo’s Comments: Another study to show that oral chondroitin sulfate is absorbed in humans.


 
 

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