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Medical Evidence

Efficacy Of Chondroprotective Agents During Gonarthritis E. S. Tzvetkova, E. R. Agababova, E. S. Mach and N. A. Bogomolova Institute of Rheumatology RAMS, Moscow, Russia

Objective: To evaluate the comparative efficacy and safety of Arthrone (chondroitin sulphate, Moscow) and Rumalon (peptide complex of glycosoaminoglycans company 'Robapharm') we carried out a long-term randomized study in 43 patients with primary gonarthritis.

Methods: Experimental and control groups were similar as to basic demographic, clinical and radiological parameters. Assessment of efficacy and safety of the two agents was performed every 6 months for 2 years applying clinical (e.g. pain, functional Lequesne index), radioIogical and some instrumental criteria. The latter were used for deep analysis of articular structure and periarticular tissues, mainly reactive synovitis. The experimental group demonstrated subsiding pain in the knee joint (from 3.19±0.29-2.3±0.29, P < 0.05), decrease of Lequesne index (from 3.7±0.65-1.88±0.3, P < 0.05) and reactive synovitis (in 75% of patients). Clinical parameters in the control group were unchanged with the exception of synovitis.

Results: Data obtained demonstrates chondroprotective properties and safety of the studied agents.


 
 

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