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Medical Evidence

Therapeutic Activity of Oral Glucosamine Sulfate in 0steoarthrosis: A Placebo-Controlled Double-Blind Investigation A. Drovanti, Vigevano General Hospital; Italy; A.A. Bignainini, Institute of Biological Chemistry, University of Pavia, Italy; A.L. Rovati, Rotta Research Laboratorium, Milano, Italy

Abstract: Eighty inpatients with established osteoarthrosis received either 1.5 gm of glucosamine sulfate (Viartril-S™) or placebo daily, in three divided oral doses, for 30 days. Articular pain, joint tenderness and swelling, and restriction of active and passive movements were scored at one week intervals, as were possible side reactions. Hematologic analysis, urine analysis, and occult blood in feces were recorded before and after treatment. Samples of articular cartilage from two patients of each group and from one healthy subject were submitted to scanning electron microscopy after the end of treatment. All symptoms decreased in both groups. The patients treated with glucosamine sulfate experienced a reduction in overall symptoms that was almost twice as large (73% vs. 41 %) and twice as fast (time to reduce symptoms by 50%: 20 days vs. 36 days) as those who had placebo. The improvement of autonomous mobility was relatively less, compared to improvement in the other symptoms, for patients with placebo; with glucosamine sulfate, on the contrary, the improvement was as great and as fast as that of the other symptoms. Thus a direct action of glucosamine sulfate on the cartilage is hypothesized.

This hypothesis is supported by the findings of electron microscopy. The patients who had placebo showed a typical picture of established osteoarthrosis. Those who had glucosamine sulfate showed a picture more similar to healthy cartilage. It is concluded that glucosamine sulfate tends to rebuild the damaged cartilage, thus restoring articular function in most chronic arthrosic patients.

Source: Clinical Therapeutics/Vol. 3, No. 4, 1980

Dr. Theo’s Comments: This study, using oral glucosamine versus placebo shows that glucosamine significantly improved pain, tenderness, range-of-motion and swelling in patients with arthritis of the knee. Furthermore, no abnormalities in blood or urine tests were noted. The conclusion by the authors is that glucosamine should be used as a first-line agent for osteoarthritis.


 
 

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